MSK2 (pThr687) Antikörper

Details zu Produkt Nr. ABIN6269729
Target
Bindungsspezifität
pThr687
13
11
10
8
8
7
7
7
4
2
2
2
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
82
62
3
2
2
1
1
Wirt
Kaninchen
81
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
8
5
5
5
5
5
5
3
3
2
2
2
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
53
37
18
17
14
6
4
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human MSK2 around the phosphorylation site of Thr687
Isotyp IgG
Spezifität Phospho-MSK2 (Thr687) Antibody detects endogenous levels of MSK2 only when phosphorylated at Thr687
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Hintergrund

Description: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

Gene: RPS6KA4

Molekulargewicht 85kDa
Gen-ID 8986
UniProt O75676
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-MSK2 (pThr687) antibody (ABIN6269729) ABIN6269730 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 2 for anti-MSK2 (pThr687) antibody (ABIN6269729) ABIN6269730 at 1/100 staining rat heart tissue sections by IHC-P. The tissue was form...
Image no. 3 for anti-MSK2 (pThr687) antibody (ABIN6269729) Western blot analysis of Phospho-MSK2 (Thr687) in lysates of HepG2, using Phospho-MSK...