SF3B1 Antikörper (Splicing Factor 3b, Subunit 1, 155kDa) (pThr211)

Details for Product anti-SF3B1 Antibody No. ABIN6269723
Target
Bindungsspezifität
pThr211
13
10
7
7
3
2
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
71
54
43
9
7
5
5
5
4
3
3
3
3
2
1
1
Wirt
Kaninchen
68
3
Klonalität
Polyklonal
Konjugat
Dieser SF3B1 Antikörper ist unkonjugiert
6
4
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
48
30
24
13
11
4
3
3
1
Optionen
Immunogen A synthesized peptide derived from human SF3B1 around the phosphorylation site of Thr211
Isotyp IgG
Spezifität Phospho-SF3B1 (Thr211) Antibody detects endogenous levels of SF3B1 only when phosphorylated at Thr211
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung SF3B1 (SF3B1 Antibody Abstract)
Hintergrund

Description: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).

Gene: SF3B1

Molekulargewicht 145kDa
Gen-ID 23451
UniProt O75533
Pathways Chromatin Binding
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) (pThr211) antibody (ABIN6269723) ABIN6269724 at 1/100 staining rat kidney cancer tissue sections by IHC-P. The tissue ...
Image no. 2 for anti-Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) (pThr211) antibody (ABIN6269723) Western blot analysis of Phospho-SF3B1 (Thr211) in lysates of fetal thymus, using Pho...
Image no. 3 for anti-Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) (pThr211) antibody (ABIN6269723) ABIN6269724 at 1/100 staining human kidney cancer tissue sections by IHC-P. The tissu...
Image no. 4 for anti-Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) (pThr211) antibody (ABIN6269723) ABIN6269724 at 1/100 staining mouse liver cancer tissue sections by IHC-P. The tissue...