TNFRSF21 Antikörper (Tumor Necrosis Factor Receptor Superfamily, Member 21) (pThr460)

Details for Product anti-TNFRSF21 Antibody No. ABIN6269721
Target
Bindungsspezifität
pThr460
9
8
7
7
7
6
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Ratte
90
14
9
1
1
1
1
Wirt
Kaninchen
68
25
4
Klonalität
Polyklonal
Konjugat
Dieser TNFRSF21 Antikörper ist unkonjugiert
10
4
4
2
2
2
2
2
2
2
2
2
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
56
43
16
15
10
8
3
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human DR6 around the phosphorylation site of Thr460
Isotyp IgG
Spezifität Phospho-DR6 (Thr460) Antibody detects endogenous levels of DR6 only when phosphorylated at Thr460
Kreuzreaktivität Human, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung DR6 (TNFRSF21 Antibody Abstract)
Hintergrund

Description: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21, this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

Gene: TNFRSF21

Molekulargewicht 72kDa
Gen-ID 27242
UniProt O75509
Pathways Regulation of Lipid Metabolism by PPARalpha
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) (pThr460) antibody (ABIN6269721) ABIN6269722 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 2 for anti-Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) (pThr460) antibody (ABIN6269721) ABIN6269722 at 1/100 staining human lung tissue sections by IHC-P. The tissue was for...
Image no. 3 for anti-Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) (pThr460) antibody (ABIN6269721) Western blot analysis of Phospho-DR6 (Thr460) in lysates of A549?, using Phospho-DR6 ...