ROCK2 Antikörper (rho-Associated, Coiled-Coil Containing Protein Kinase 2) (pSer1379)

Details for Product anti-ROCK2 Antibody No. ABIN6269701
Target
Bindungsspezifität
pSer1379
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16
9
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3
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3
2
2
2
2
2
2
2
1
1
1
1
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1
Reaktivität
Human, Maus, Ratte
132
108
108
6
4
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3
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2
1
1
1
1
1
1
Wirt
Kaninchen
128
8
1
Klonalität
Polyklonal
Konjugat
Dieser ROCK2 Antikörper ist unkonjugiert
9
7
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2
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
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26
13
10
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2
1
Optionen
Immunogen A synthesized peptide derived from human ROCK2 around the phosphorylation site of Ser1379
Isotyp IgG
Spezifität Phospho-ROCK2 (Ser1379) Antibody detects endogenous levels of ROCK2 only when phosphorylated at Ser1379
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung ROCK2 (ROCK2 Antibody Abstract)
Hintergrund

Description: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca2+ sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

Gene: ROCK2

Molekulargewicht 165kDa
Gen-ID 9475
UniProt O75116
Pathways Microtubule Dynamics, WNT Signalweg, Tube Formation
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (pSer1379) antibody (ABIN6269701) Western blot analysis of Phospho-ROCK2 (Ser1379) in lysates of HeLa?, using Phospho-R...
Image no. 2 for anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (pSer1379) antibody (ABIN6269701) ABIN6269702 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...
Image no. 3 for anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (pSer1379) antibody (ABIN6269701) ABIN6269702 at 1/100 staining mouse heart tissue sections by IHC-P. The tissue was fo...
Image no. 4 for anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (pSer1379) antibody (ABIN6269701) ABIN6269702 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...