Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (pSer301) Antikörper

Details zu Produkt Nr. ABIN6269673
Target
Bindungsspezifität
pSer301
9
8
8
7
7
4
2
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
43
40
17
1
1
1
1
1
Wirt
Kaninchen
53
6
1
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
43
23
13
9
9
6
4
2
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human SGTA around the phosphorylation site of Ser301
Isotyp IgG
Spezifität Phospho-SGTA (Ser301) Antibody detects endogenous levels of SGTA only when phosphorylated at Ser301
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung SGTA (SGTA Antibody Abstract)
Hintergrund

Description: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).

Gene: SGTA

Molekulargewicht 34kDa
Gen-ID 6449
UniProt O43765
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (pSer301) antibody (ABIN6269673) ABIN6269674 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 2 for anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (pSer301) antibody (ABIN6269673) Western blot analysis of extracts of Mouse liver tissue sample,using Phospho-SGTA (Se...
Image no. 3 for anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (pSer301) antibody (ABIN6269673) ABIN6269674 at 1/100 staining rat kidney tissue sections by IHC-P. The tissue was for...
Image no. 4 for anti-Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA) (pSer301) antibody (ABIN6269673) ABIN6269674 at 1/100 staining mouse heart tissue sections by IHC-P. The tissue was fo...