LAT Antikörper (Linker For Activation of T Cells) (pTyr45)

Details for Product anti-LAT Antibody No. ABIN6269667
Target
Bindungsspezifität
pTyr45
18
18
14
9
8
7
7
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
158
99
93
2
Wirt
Kaninchen
137
16
7
1
Klonalität
Polyklonal
Konjugat
Dieser LAT Antikörper ist unkonjugiert
9
8
7
6
6
6
6
5
3
3
3
3
3
3
2
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
102
52
39
25
20
13
9
8
3
1
1
1
Optionen
Immunogen A synthesized peptide derived from human LAT around the phosphorylation site of Tyr45
Isotyp IgG
Spezifität Phospho-LAT (Tyr45) Antibody detects endogenous levels of LAT only when phosphorylated at Tyr45
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung LAT (LAT Antibody Abstract)
Hintergrund

Description: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Gene: LAT

Molekulargewicht 28kDa
Gen-ID 27040
UniProt O43561
Pathways T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Linker For Activation of T Cells (LAT) (pTyr45) antibody (ABIN6269667) ABIN6269668 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 2 for anti-Linker For Activation of T Cells (LAT) (pTyr45) antibody (ABIN6269667) Western blot analysis of Phospho-LAT (Tyr45) in lysates of NIH-3T3, using Phospho-LAT...
Image no. 3 for anti-Linker For Activation of T Cells (LAT) (pTyr45) antibody (ABIN6269667) ABIN6269668 at 1/100 staining rat heart tissue sections by IHC-P. The tissue was form...
Image no. 4 for anti-Linker For Activation of T Cells (LAT) (pTyr45) antibody (ABIN6269667) ABIN6269668 at 1/100 staining mouse kidney tissue sections by IHC-P. The tissue was f...