FOXO3 Antikörper (Forkhead Box O3) (pSer284)

Details for Product anti-FOXO3 Antibody No. ABIN6269661
Target
Bindungsspezifität
pSer284
33
20
14
10
10
9
9
9
9
9
8
8
8
7
7
7
7
5
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
228
153
143
12
10
7
7
6
6
6
5
4
3
3
3
1
1
Wirt
Kaninchen
210
13
7
1
Klonalität
Polyklonal
Konjugat
Dieser FOXO3 Antikörper ist unkonjugiert
19
13
12
12
11
11
11
8
7
5
5
5
2
2
2
2
2
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
148
97
85
40
37
27
15
11
11
4
3
3
3
2
1
1
Optionen
Immunogen A synthesized peptide derived from human FoxO3a around the phosphorylation site of Ser284
Isotyp IgG
Spezifität Phospho-FoxO3a (Ser284) Antibody detects endogenous levels of FoxO3a only when phosphorylated at Ser284
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung FoxO3a (FOXO3 Antibody Abstract)
Hintergrund

Description: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).

Gene: FOXO3

Molekulargewicht 97kDa
Gen-ID 2309
UniProt O43524
Pathways Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Forkhead Box O3 (FOXO3) (pSer284) antibody (ABIN6269661) ABIN6269662 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 2 for anti-Forkhead Box O3 (FOXO3) (pSer284) antibody (ABIN6269661) ABIN6269662 at 1/100 staining rat kidney tissue sections by IHC-P. The tissue was for...
Image no. 3 for anti-Forkhead Box O3 (FOXO3) (pSer284) antibody (ABIN6269661) ABIN6269662 at 1/100 staining mouse kidney tissue sections by IHC-P. The tissue was f...
Image no. 4 for anti-Forkhead Box O3 (FOXO3) (pSer284) antibody (ABIN6269661) Western blot analysis of Phospho-FoxO3a (Ser284) in lysates of Jurkat?, using Phospho...