BIM Antikörper (BCL2-Like 11 (Apoptosis Facilitator)) (pSer118)

Details for Product anti-BCL2L11 Antibody No. ABIN6269659
Target
Bindungsspezifität
pSer118
47
19
15
15
15
11
9
9
8
8
8
8
8
8
7
7
6
6
5
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
302
218
205
9
5
4
3
3
2
1
1
Wirt
Kaninchen
277
12
8
7
4
Klonalität
Polyklonal
Konjugat
Dieser BIM Antikörper ist unkonjugiert
22
13
12
10
9
9
9
9
9
9
9
9
4
4
4
4
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
228
124
90
46
43
38
28
27
22
15
6
6
2
2
2
2
2
2
1
Optionen
Immunogen A synthesized peptide derived from human Bim around the phosphorylation site of Ser118
Isotyp IgG
Spezifität Phospho-Bim (Ser118) Antibody detects endogenous levels of Bim only when phosphorylated at Ser118
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung Bim (BCL2L11 Antibody Abstract)
Hintergrund

Description: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

Gene: BCL2L11

Molekulargewicht 25kDa,22kDa
Gen-ID 10018
UniProt O43521
Pathways PI3K-Akt Signalweg, Neurotrophin Signalübertragung, Tube Formation, Positive Regulation of Endopeptidase Activity
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer118) antibody (ABIN6269659) ABIN6269660 at 1/100 staining mouse liver tissue sections by IHC-P. The tissue was fo...
Image no. 2 for anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer118) antibody (ABIN6269659) ABIN6269660 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 3 for anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer118) antibody (ABIN6269659) ABIN6269660 at 1/100 staining rat liver tissue sections by IHC-P. The tissue was form...
Image no. 4 for anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) (pSer118) antibody (ABIN6269659) Western blot analysis of Phospho-Bim (Ser118) in lysates of K562?, using Phospho-Bim ...