Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (pSer389) Antikörper

Details zu Produkt Nr. ABIN6269649
Target
Bindungsspezifität
pSer389
35
35
24
16
15
15
15
15
15
11
9
9
7
5
5
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
236
174
170
10
7
7
5
5
4
4
4
3
2
2
1
1
Wirt
Kaninchen
219
17
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
16
13
11
11
10
10
10
9
9
6
6
6
6
6
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
141
79
61
57
36
7
3
2
2
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human TAK1 around the phosphorylation site of Ser389 Antibody
Isotyp IgG
Spezifität Phospho-TAK1 (Ser389 Antibody detects endogenous levels of TAK1 only when phosphorylated at Ser389 Antibody
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung TAK1 (NR2C2 Antibody Abstract)
Hintergrund

Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

Gene: MAP3K7

Molekulargewicht 70kDa
Gen-ID 6885
UniProt O43318
Pathways T-Zell Rezeptor Signalweg, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (pSer389) antibody (ABIN6269649) Western blot analysis of Phospho-TAK1 (Ser389 in lysates of NIH/3T3?, using Phospho-T...