BIRC5 Antikörper (Baculoviral IAP Repeat-Containing 5) (pThr48)

Details for Product anti-BIRC5 Antibody No. ABIN6269645
Target
Bindungsspezifität
pThr48
18
17
16
11
7
7
6
5
5
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
163
82
75
2
2
2
1
1
1
Wirt
Kaninchen
131
37
7
1
Klonalität
Polyklonal
Konjugat
Dieser BIRC5 Antikörper ist unkonjugiert
17
10
5
4
4
4
4
4
4
3
2
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
122
64
53
52
27
27
25
13
13
7
6
4
4
2
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human Survivin around the phosphorylation site of Thr48
Isotyp IgG
Spezifität Phospho-Survivin (Thr48) Antibody detects endogenous levels of Survivin only when phosphorylated at Thr48
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung Survivin (BIRC5 Antibody Abstract)
Hintergrund

Description: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).

Gene: BIRC5

Molekulargewicht 16kDa
Gen-ID 332
UniProt O15392
Pathways Apoptose, Zellzyklus, Nuclear Hormone Receptor Binding
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (pThr48) antibody (ABIN6269645) ABIN6269646 at 1/100 staining rat kidney tissue sections by IHC-P. The tissue was for...
Image no. 2 for anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (pThr48) antibody (ABIN6269645) Western blot analysis of extracts of Mouse kidney tissue sample,using Phospho-Surviv...
Image no. 3 for anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (pThr48) antibody (ABIN6269645) ABIN6269646 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 4 for anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (pThr48) antibody (ABIN6269645) ABIN6269646 at 1/100 staining mouse kidney tissue sections by IHC-P. The tissue was f...