MDM4-binding Protein Antikörper (Mdm4-binding Protein) (pSer342)

Details for Product anti-MDM4 Antibody No. ABIN6269637
Target
Bindungsspezifität
pSer342
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4
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2
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Reaktivität
Human, Maus, Ratte
90
49
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4
3
3
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1
1
Wirt
Kaninchen
77
13
1
Klonalität
Polyklonal
Konjugat
Dieser MDM4-binding Protein Antikörper ist unkonjugiert
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4
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Applikation
ELISA, Western Blotting (WB)
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1
Optionen
Immunogen A synthesized peptide derived from human MDM4 around the phosphorylation site of Ser342
Isotyp IgG
Spezifität Phospho-MDM4 (Ser342) Antibody detects endogenous levels of MDM4 only when phosphorylated at Ser342
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung MDM4 (MDM4 Antibody Abstract)
Hintergrund

Description: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

Gene: MDM4

Molekulargewicht 55kDa
Gen-ID 4194
UniProt O15151
Pathways Zellzyklus
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Mdm4-binding Protein (MDM4) (pSer342) antibody (ABIN6269637) Western blot analysis of Phospho-MDM4 (Ser342) in lysates of HeLa calyculinA 50ng/ml ...