MUSK Antikörper (Muscle, Skeletal, Receptor Tyrosine Kinase) (pTyr755)

Details for Product anti-MUSK Antibody No. ABIN6269633
Target
Bindungsspezifität
pTyr755
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10
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Reaktivität
Human, Maus, Ratte
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2
2
1
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Wirt
Kaninchen
83
16
3
Klonalität
Polyklonal
Konjugat
Dieser MUSK Antikörper ist unkonjugiert
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5
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Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
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Optionen
Immunogen A synthesized peptide derived from human MuSK around the phosphorylation site of Tyr755
Isotyp IgG
Spezifität Phospho-MuSK (Tyr755) Antibody detects endogenous levels of MuSK only when phosphorylated at Tyr755
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung MuSK (MUSK Antibody Abstract)
Hintergrund

Description: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).

Gene: MUSK

Molekulargewicht 97kDa
Gen-ID 4593
UniProt O15146
Pathways RTK Signalweg, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (pTyr755) antibody (ABIN6269633) ABIN6269634 at 1/100 staining rat brain tissue sections by IHC-P. The tissue was form...
Image no. 2 for anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (pTyr755) antibody (ABIN6269633) Western blot analysis of Phospho-MuSK (Tyr755) in lysates of JK, using Phospho-MuSK (...