Dynamin 1-Like (DNM1L) (pSer529) Antikörper

Details zu Produkt Nr. ABIN6269617
Target
Bindungsspezifität
pSer529
18
10
7
4
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
85
57
52
5
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Wirt
Kaninchen
77
9
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
5
5
5
5
4
4
3
2
2
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
48
35
30
17
15
12
11
6
5
3
1
Optionen
Immunogen A synthesized peptide derived from human DRP1 around the phosphorylation site of Ser529
Isotyp IgG
Spezifität Phospho-DRP1 (Ser529) Antibody detects endogenous levels of DRP1 only when phosphorylated at Ser529
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung DRP1 (DNM1L Antibody Abstract)
Hintergrund

Description: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis (PubMed:26992161). Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.

Gene: DNM1L

Molekulargewicht 79kDa
Gen-ID 10059
UniProt O00429
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Dynamin 1-Like (DNM1L) (pSer529) antibody (ABIN6269617) ABIN6269618 at 1/100 staining mouse brain tissue sections by IHC-P. The tissue was fo...
Image no. 2 for anti-Dynamin 1-Like (DNM1L) (pSer529) antibody (ABIN6269617) ABIN6269618 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 3 for anti-Dynamin 1-Like (DNM1L) (pSer529) antibody (ABIN6269617) Western blot analysis of Phospho-DRP1 (Ser529) in lysates of HeLa?, using Phospho-DRP...