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Dynamin 1-Like (DNM1L) (pSer529) Antikörper Primary Antibody

DNM1L Reaktivität: Human, Maus, Ratte ELISA, IHC, WB Wirt: Kaninchen Polyclonal
Produktnummer ABIN6269617
$450.00
Zzgl. Versandkosten $45.00
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 12 Werktagen
  • Target
    Bindungsspezifität
    pSer529
    Reaktivität
    Human, Maus, Ratte
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Konjugat
    Unkonjugiert
    Applikation
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    Spezifität
    Phospho-DRP1 (Ser529) Antibody detects endogenous levels of DRP1 only when phosphorylated at Ser529
    Kreuzreaktivität
    Human, Maus, Ratte (Rattus)
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human DRP1 around the phosphorylation site of Ser529
    Isotyp
    IgG
  • Target
    Andere Bezeichnung
    DRP1 (DNM1L Antibody Abstract)
    Hintergrund

    Description: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis (PubMed:26992161). Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.

    Gene: DNM1L

    Molekulargewicht
    79kDa
    Gen-ID
    10059
    UniProt
    O00429
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
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