SMYD2A Antikörper (SET and MYND Domain Containing 2a) (pSer283)

Details for Product anti-SMYD2A Antibody No. ABIN6269599
Target
Bindungsspezifität
pSer283
7
6
5
4
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
48
34
20
6
6
4
4
4
3
3
2
2
1
Wirt
Kaninchen
44
4
Klonalität
Polyklonal
Konjugat
Dieser SMYD2A Antikörper ist unkonjugiert
3
2
2
2
2
2
2
1
1
Applikation
ELISA, Western Blotting (WB)
31
14
5
3
3
2
1
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human SMYD2 around the phosphorylation site of Ser283
Isotyp IgG
Spezifität Phospho-SMYD2(Ser283) Antibody detects endogenous levels of SMYD2 only when phosphorylated at Ser283
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung SMYD2 (SMYD2A Antibody Abstract)
Hintergrund

Description: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.

Gene: SMYD2

Molekulargewicht 49kDa
Gen-ID 56950
UniProt Q9NRG4
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-SET and MYND Domain Containing 2a (SMYD2A) (pSer283) antibody (ABIN6269599) Western blot analysis of Phospho-SMYD2(Ser283) in lysates of NIH 3T3, using Phospho-S...