PINK1 Antikörper (PTEN Induced Putative Kinase 1) (pSer228)

Details for Product anti-PINK1 Antibody No. ABIN6269579
Target
Bindungsspezifität
pSer228
41
17
12
9
7
7
7
7
7
7
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
143
89
59
2
2
1
1
1
Wirt
Kaninchen
97
62
7
1
Klonalität
Polyklonal
Konjugat
Dieser PINK1 Antikörper ist unkonjugiert
11
10
8
8
8
8
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
139
86
81
32
28
14
4
3
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human PINK1 around the phosphorylation site of Ser228
Isotyp IgG
Spezifität Phospho-PINK1(Ser228) Antibody detects endogenous levels of PINK1 only when phosphorylated at Ser228
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung PINK1 (PINK1 Antibody Abstract)
Hintergrund

Description: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).

Gene: PINK1

Molekulargewicht 66kDa
Gen-ID 65018
UniProt Q9BXM7
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-PTEN Induced Putative Kinase 1 (PINK1) (pSer228) antibody (ABIN6269579) ABIN6269580 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was f...
Image no. 2 for anti-PTEN Induced Putative Kinase 1 (PINK1) (pSer228) antibody (ABIN6269579) Western blot analysis of Phospho-PINK1(Ser228) in lysates of Jurkat?, using Phospho-P...