FBP1 Antikörper (Fructose-1,6-Bisphosphatase 1) (pTyr265)

Details for Product anti-FBP1 Antibody No. ABIN6269537
Target
Bindungsspezifität
pTyr265
15
12
7
5
3
3
3
2
2
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
80
60
50
2
2
2
1
1
1
1
Wirt
Kaninchen
77
3
2
Klonalität
Polyklonal
Konjugat
Dieser FBP1 Antikörper ist unkonjugiert
7
5
3
3
3
3
3
3
3
2
2
2
2
2
1
1
1
Applikation
ELISA, Western Blotting (WB)
48
26
19
14
12
7
7
5
4
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human FBP1 around the phosphorylation site of Tyr265
Isotyp IgG
Spezifität Phospho-FBP1(Tyr265) Antibody detects endogenous levels of FBP1 only when phosphorylated at Tyr265
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung FBP1 (FBP1 Antibody Abstract)
Hintergrund

Description: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity, increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Gene: FBP1

Molekulargewicht 37kDa
Gen-ID 2203
UniProt P09467
Pathways Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Dicarboxylic Acid Transport
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Fructose-1,6-Bisphosphatase 1 (FBP1) (pTyr265) antibody (ABIN6269537) Western blot analysis of extracts of Mouse kidney tissue sample,using Phospho-FBP1(Ty...