SETD8 Antikörper (SET Domain Containing (Lysine Methyltransferase) 8) (pSer100)

Details for Product anti-SETD8 Antibody No. ABIN6269523
Target
Bindungsspezifität
pSer100
30
10
8
7
7
4
2
2
2
2
1
1
1
Reaktivität
Human, Maus, Ratte
100
37
19
Wirt
Kaninchen
77
23
Klonalität
Polyklonal
Konjugat
Dieser SETD8 Antikörper ist unkonjugiert
8
8
7
7
7
5
2
2
2
2
2
2
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
77
57
41
11
10
9
5
4
2
1
Optionen
Immunogen A synthesized peptide derived from human KMT5A around the phosphorylation site of Ser100
Isotyp IgG
Spezifität Phospho-KMT5A(Ser100) Antibody detects endogenous levels of KMT5A only when phosphorylated at Ser100
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung KMT5A (SETD8 Antibody Abstract)
Hintergrund

Description: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

Gene: KMT5A

Molekulargewicht 43kDa
Gen-ID 387893
UniProt Q9NQR1
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) (pSer100) antibody (ABIN6269523) Western blot analysis of Phospho-KMT5A(Ser100) in lysates of 293T, using Phospho-KMT5...