KCNA1 Antikörper (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1) (pSer446)

Details for Product anti-KCNA1 Antibody No. ABIN6269503
Target
  • AEMK
  • EA1
  • HBK1
  • HUK1
  • KV1.1
  • MBK1
  • MK1
  • RBK1
  • KCNA1
  • AI840627
  • Kca1-1
  • Kv1.1
  • Mk-1
  • Shak
  • mceph
  • Kcna
  • Kcpvd
  • potassium voltage-gated channel subfamily A member 1
  • potassium voltage-gated channel, shaker-related subfamily, member 1
  • fragile site, aphidicolin type, common, fra(12)(q24)
  • KCNA1
  • Kcna1
  • FRA12E
Bindungsspezifität
pSer446
12
10
10
8
7
7
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human
82
38
36
5
5
2
2
1
1
1
Wirt
Kaninchen
79
11
Klonalität
Polyklonal
Konjugat
Dieser KCNA1 Antikörper ist unkonjugiert
10
6
6
4
2
2
2
2
2
2
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
66
40
29
13
9
7
5
5
3
2
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human KCNA1 around the phosphorylation site of Ser446
Isotyp IgG
Spezifität Phospho-KCNA1(Ser446) Antibody detects endogenous levels of KCNA1 only when phosphorylated at Ser446
Kreuzreaktivität Human
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung KCNA1 (KCNA1 Antibody Abstract)
Hintergrund

Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well, channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:12077175, PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:19968958, PubMed:19307729, PubMed:19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:11026449, PubMed:17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg2+ in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:23903368, PubMed:19307729).

Gene: KCNA1

Molekulargewicht 57kDa
Gen-ID 3736
UniProt Q09470
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1) (pSer446) antibody (ABIN6269503) Western blot analysis of Phospho-KCNA1(Ser446) in lysates of HuvEc , using Phospho-KC...