DEPDC5 Antikörper (DEP Domain Containing 5)

Details for Product anti-DEPDC5 Antibody No. ABIN6269473
Target
Reaktivität
Human
11
Wirt
Kaninchen
11
Klonalität
Polyklonal
Konjugat
Dieser DEPDC5 Antikörper ist unkonjugiert
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
11
10
7
1
1
Optionen
Immunogen A synthesized peptide derived from human DEPDC5
Isotyp IgG
Spezifität DEPDC5 Antibody detects endogenous levels of DEPDC5
Kreuzreaktivität Human
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung DEPDC5
Hintergrund

Description: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.

Gene: DEPDC5

Molekulargewicht 180 kDa
Gen-ID 9681
UniProt O75140
Applikations-hinweise WB 1:1000-3000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-DEP Domain Containing 5 (DEPDC5) antibody (ABIN6269473) Western blot analysis of DEPDC5 expression in HeLa lysate