INCENP Antikörper (Inner Centromere Protein Antigens 135/155kDa)

Details for Product anti-INCENP Antibody No. ABIN6269469
Target
Reaktivität
Human, Maus, Ratte
30
13
11
1
1
1
Wirt
Kaninchen
17
13
Klonalität
Polyklonal
Konjugat
Dieser INCENP Antikörper ist unkonjugiert
2
2
2
2
2
2
2
Applikation
ELISA, Western Blotting (WB)
17
9
8
7
6
4
1
1
Optionen
Immunogen A synthesized peptide derived from human INCENP
Isotyp IgG
Spezifität INCENP Antibody detects endogenous levels of INCENP
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung INCENP (INCENP Antibody Abstract)
Hintergrund

Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428).

Gene: INCENP

Molekulargewicht 105.4kDa
Gen-ID 3619
UniProt Q9NQS7
Pathways Zellzyklus
Applikations-hinweise WB 1:1000-3000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Inner Centromere Protein Antigens 135/155kDa (INCENP) antibody (ABIN6269469) Western blot analysis of extracts from Mouse lung, using INCENP Antibody. The lane on...