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Caspase 3 Antikörper (CASP3) Primary Antibody

CASP3 Reaktivität: Human, Maus, Ratte ELISA, ICC, IF, IHC, WB Wirt: Kaninchen Polyclonal
Pubmed (12)
Produktnummer ABIN6269461
$450.00
Zzgl. Versandkosten $45.00
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 12 Werktagen
  • Target
    Reaktivität
    Human, Maus, Ratte
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Konjugat
    Dieser Caspase 3 Antikörper ist unkonjugiert
    Applikation
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
    Spezifität
    Caspase 3 (p17,Cleaved-Asp175) Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.
    Kreuzreaktivität
    Human, Maus, Ratte (Rattus)
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    The antiserum was produced against synthesized peptide derived from human Caspase 3.
    Isotyp
    IgG
  • Target
    Andere Bezeichnung
    caspase 3 (CASP3 Antibody Abstract)
    Hintergrund

    Description: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

    Gene: CASP3

    Molekulargewicht
    17kDa
    Gen-ID
    836
    UniProt
    P42574
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
  • Applikationshinweise
    WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.Store at -20 °C.Stable for 13 months from date of receipt
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Song, Zhang, Sun, Li, Chen, Xiao, Xing: "AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells." in: Oncotarget, Vol. 8, Issue 40, pp. 67942-67954, 2018 (PubMed).

    Zhang, Fei, Tao, Li, Shen, Wang, Liu, Xu: "Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF-κB Signaling Pathway." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 3848595, 2018 (PubMed).

    Zhao, Fu, Sun, Liu: "Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia." in: IUBMB life, Vol. 70, Issue 1, pp. 60-70, 2018 (PubMed).

    Yin, Meng, Zhang, Hu, Chen, Han, Wu, You, Li, Jin, Guan: "Bacillus spore-based oral carriers loading curcumin for the therapy of colon cancer." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 271, pp. 31-44, 2018 (PubMed).

    Liu, Tang, Liu, Zhang, He, Li, Gao, Tang, Jin, Kong: "Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance." in: Cell death & disease, Vol. 9, Issue 4, pp. 419, 2018 (PubMed).

    Zheng, Zhu, Yang, Chai, Liu, Li, Ren, Ji, Liu, Li: "The co-treatment of metformin with flavone synergistically induces apoptosis through inhibition of PI3K/AKT pathway in breast cancer cells." in: Oncology letters, Vol. 15, Issue 4, pp. 5952-5958, 2018 (PubMed).

    Liang, Zhang, Zeng, Guan, Xiao, Xiao: "The role of IP3R-SOCCs in Cr(vi)-induced cytosolic Ca2+ overload and apoptosis in L-02 hepatocytes." in: Toxicology research, Vol. 7, Issue 3, pp. 521-528, 2018 (PubMed).

    Li, Li, Hu, Lian, Wang, Fu: "Transcription factor 3 controls cell proliferation and migration in glioblastoma multiforme cell lines." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 94, Issue 3, pp. 247-55, 2017 (PubMed).

    Chen, Niu, Ma, Zhang, Gao, Fan, Pang, Gong, Shen, Gu, Zhang, Zhang: "RhoB Acts as a Tumor Suppressor That Inhibits Malignancy of Clear Cell Renal Cell Carcinoma." in: PLoS ONE, Vol. 11, Issue 7, pp. e0157599, 2017 (PubMed).

    Ding, Weng, Fan, Cao, Lu: "Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay." in: Frontiers in molecular neuroscience, Vol. 10, pp. 121, 2017 (PubMed).

    Wu, Huang, Jiao, Ding, Zhang, Chen, Wang, Li, Huo: "Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells." in: Oncotarget, Vol. 8, Issue 51, pp. 88630-88644, 2017 (PubMed).

    Chen, Deng, Xiong, Zhang, Yang, Hu: "A ROS-mediated lysosomal-mitochondrial pathway is induced by ginsenoside Rh2 in hepatoma HepG2 cells." in: Food & function, Vol. 6, Issue 12, pp. 3828-37, 2016 (PubMed).

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