Caspase 3 Antikörper (CASP3)

Details for Product anti-CASP3 Antibody No. ABIN6269461
Target
  • CPP32
  • CPP32B
  • SCA-1
  • A830040C14Rik
  • AC-3
  • Apopain
  • CC3
  • Caspase-3
  • Lice
  • Yama
  • mldy
  • xcpp32
  • casp3
  • zgc:100890
  • CASP-3
  • caspase-3
  • caspase 3
  • caspase 3 S homeolog
  • caspase 3, apoptosis-related cysteine peptidase a
  • caspase 3, apoptosis-related cysteine peptidase
  • CASP3
  • Casp3
  • casp3.S
  • casp3a
Reaktivität
Human, Maus, Ratte
310
190
167
37
21
18
18
17
17
10
10
9
5
4
4
3
2
2
1
Wirt
Kaninchen
305
51
9
2
2
Klonalität
Polyklonal
Konjugat
Dieser Caspase 3 Antikörper ist unkonjugiert
28
21
14
9
8
8
8
8
7
7
7
7
2
2
2
2
2
2
2
1
1
Applikation
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
247
148
132
71
47
35
34
33
29
28
14
12
9
9
5
2
1
1
1
Optionen
Immunogen The antiserum was produced against synthesized peptide derived from human Caspase 3.
Isotyp IgG
Spezifität Caspase 3 (p17,Cleaved-Asp175) Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung caspase 3 (CASP3 Antibody Abstract)
Hintergrund

Description: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Gene: CASP3

Molekulargewicht 17kDa
Gen-ID 836
UniProt P42574
Pathways Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
Applikations-hinweise WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.Store at -20 °C.Stable for 13 months from date of receipt
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Bilder
Image no. 1 for anti-Caspase 3 (CASP3) antibody (ABIN6269461) Western blot analysis of extracts from COLO cells, using Caspase 3 (p17,Cleaved-Asp17...
Image no. 2 for anti-Caspase 3 (CASP3) antibody (ABIN6269461) ABIN6269462 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized...
Image no. 3 for anti-Caspase 3 (CASP3) antibody (ABIN6269461) ABIN6269462 at 1/100 staining Mouse brain tissue by IHC-P. The sample was formaldehyd...
Image no. 4 for anti-Caspase 3 (CASP3) antibody (ABIN6269461) Immunohistochemical staining of formalin fixed paraffin-embedded ehrlich carcimoma ti...
Produkt verwendet in: Song, Zhang, Sun, Li, Chen, Xiao, Xing: "AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells." in: Oncotarget, Vol. 8, Issue 40, pp. 67942-67954, 2018 (PubMed).

Zhang, Fei, Tao, Li, Shen, Wang, Liu, Xu: "Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF-κB Signaling Pathway." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 3848595, 2018 (PubMed).

Zhao, Fu, Sun, Liu: "Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia." in: IUBMB life, Vol. 70, Issue 1, pp. 60-70, 2018 (PubMed).

Yin, Meng, Zhang, Hu, Chen, Han, Wu, You, Li, Jin, Guan: "Bacillus spore-based oral carriers loading curcumin for the therapy of colon cancer." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 271, pp. 31-44, 2018 (PubMed).

Liu, Tang, Liu, Zhang, He, Li, Gao, Tang, Jin, Kong: "Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance." in: Cell death & disease, Vol. 9, Issue 4, pp. 419, 2018 (PubMed).

Zheng, Zhu, Yang, Chai, Liu, Li, Ren, Ji, Liu, Li: "The co-treatment of metformin with flavone synergistically induces apoptosis through inhibition of PI3K/AKT pathway in breast cancer cells." in: Oncology letters, Vol. 15, Issue 4, pp. 5952-5958, 2018 (PubMed).

Liang, Zhang, Zeng, Guan, Xiao, Xiao: "The role of IP3R-SOCCs in Cr(vi)-induced cytosolic Ca2+ overload and apoptosis in L-02 hepatocytes." in: Toxicology research, Vol. 7, Issue 3, pp. 521-528, 2018 (PubMed).

Li, Li, Hu, Lian, Wang, Fu: "Transcription factor 3 controls cell proliferation and migration in glioblastoma multiforme cell lines." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 94, Issue 3, pp. 247-55, 2017 (PubMed).

Chen, Niu, Ma, Zhang, Gao, Fan, Pang, Gong, Shen, Gu, Zhang, Zhang: "RhoB Acts as a Tumor Suppressor That Inhibits Malignancy of Clear Cell Renal Cell Carcinoma." in: PLoS ONE, Vol. 11, Issue 7, pp. e0157599, 2017 (PubMed).

Ding, Weng, Fan, Cao, Lu: "Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay." in: Frontiers in molecular neuroscience, Vol. 10, pp. 121, 2017 (PubMed).

Wu, Huang, Jiao, Ding, Zhang, Chen, Wang, Li, Huo: "Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells." in: Oncotarget, Vol. 8, Issue 51, pp. 88630-88644, 2017 (PubMed).

Chen, Deng, Xiong, Zhang, Yang, Hu: "A ROS-mediated lysosomal-mitochondrial pathway is induced by ginsenoside Rh2 in hepatoma HepG2 cells." in: Food & function, Vol. 6, Issue 12, pp. 3828-37, 2016 (PubMed).