Tumor Necrosis Factor Antikörper (Tumor Necrosis Factor alpha)

Details for Product anti-TNF Antibody No. ABIN6269443
Target
  • DIF
  • TNF-alpha
  • TNFA
  • TNFSF2
  • RATTNF
  • Tnfa
  • tnf
  • TNF-a
  • TNFalpha
  • Tnfsf1a
  • TNFa
  • cTNF
  • Tnf-alpha
  • tnfa-like
  • TNF-ALPHA
  • dif
  • tnfa
  • xtnf
  • tnfsf2
  • tnf-alpha
  • Cachectin
  • tumor necrosis factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • tumor necrosis factor alpha
  • tumor necrosis factor a (TNF superfamily, member 2)
  • TNF
  • Tnf
  • tnf
  • tnfb
  • tnf-alpha
  • LOC103694380
  • tnfa
Reaktivität
Human, Maus, Ratte
491
216
193
78
74
61
60
40
33
33
23
10
10
6
6
5
4
4
3
3
3
3
2
2
1
1
1
1
Wirt
Kaninchen
339
289
44
34
9
6
4
3
2
2
2
1
Klonalität
Polyklonal
Konjugat
Dieser Tumor Necrosis Factor Antikörper ist unkonjugiert
101
55
21
20
16
8
8
8
8
8
8
8
8
8
8
8
8
8
8
6
5
5
5
5
5
2
2
2
2
2
2
2
1
Applikation
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
343
327
257
234
163
84
65
56
55
53
36
35
26
25
16
11
10
10
8
7
7
7
6
6
5
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human TNFA
Isotyp IgG
Spezifität TNFA Antibody detects endogenous levels of total TNFA
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung TNFA (TNF Antibody Abstract)
Hintergrund

Description: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).

Gene: TNF

Molekulargewicht 17/30-35kDa
Gen-ID 7124
UniProt P01375
Pathways NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
Applikations-hinweise WB 1:500 IHC 1:50-1:200 IF/ICC 1:100-1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer PBS,  pH 7.4,50 % glycerol.
Bilder
Image no. 1 for anti-Tumor Necrosis Factor alpha (TNF) antibody (ABIN6269443) Western blot analysis of extracts from COLO cells,using TNFA Antibody.The lane on the...
Image no. 2 for anti-Tumor Necrosis Factor alpha (TNF) antibody (ABIN6269443) Western blot analysis of extracts of various celllines,using TNFA antibody.
Image no. 3 for anti-Tumor Necrosis Factor alpha (TNF) antibody (ABIN6269443) Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, usin...
Image no. 4 for anti-Tumor Necrosis Factor alpha (TNF) antibody (ABIN6269443) ABIN6269444 staining A-431 cells by IF/ICC. The sample were fixed with PFA and permea...
Produkt verwendet in: Sun, Xu, Yi, Chen, Wu, Cao, Zhou, Jiang, Zhang: "Role of 5-HT1A receptor in insular cortex mediating stress - induced visceral sensory dysfunction." in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, Vol. 28, Issue 7, pp. 1104-13, 2018 (PubMed).

Feng, Cui, Liu, Wu, Hu, Zhang, Ma, Wang: "Protective Role of Apocynin via Suppression of Neuronal Autophagy and TLR4/NF-κB Signaling Pathway in a Rat Model of Traumatic Brain Injury." in: Neurochemical research, Vol. 42, Issue 11, pp. 3296-3309, 2018 (PubMed).

Hu, Cheng, Huang, Cai, Lian, Wang, Gao: "Effects of Xin-Ji-Er-Kang on heart failure induced by myocardial infarction: Role of inflammation, oxidative stress and endothelial dysfunction." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 42, pp. 245-257, 2018 (PubMed).

Sheng, Wang, Guo, Xu, Jiang, Zheng, Xu, Zhang, Che, Liang, Zhu, Li: "Effects of Baicalin on Diabetic Cardiac Autonomic Neuropathy Mediated by the P2Y12 Receptor in Rat Stellate Ganglia." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 46, Issue 3, pp. 986-998, 2018 (PubMed).

Zhu, Xu, Lv, He, Ye, Wang, Hu: "miR-199b-5p Regulates Immune-Mediated Allograft Rejection after Lung Transplantation Through the GSK3β and NF-κB Pathways." in: Inflammation, Vol. 41, Issue 4, pp. 1524-1535, 2018 (PubMed).

Guo, Sheng, Dan, Xu, Zhang, Ji, Wang, Xu, Che, Li, Liang, Li: "Involvement of P2Y12 receptor of stellate ganglion in diabetic cardiovascular autonomic neuropathy." in: Purinergic signalling, 2018 (PubMed).

Yuan, Ouyang, Yang, Li, Gong, Zou, Jia, Zhao, Wu, Yi, Liu, Shi, Li, Gao, Li, Xu, Liu, Zhang, Liang: "Osthole alleviated diabetic neuropathic pain mediated by the P2X4 receptor in dorsal root ganglia." in: Brain research bulletin, Vol. 142, pp. 289-296, 2018 (PubMed).

Feng, Gao, Cui, Li, Li, Cui, Cui: "Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway." in: Cellular and molecular neurobiology, Vol. 37, Issue 1, pp. 155-168, 2017 (PubMed).

Zhang, Zou, Zhang, Fu, Xu, Wang, Xia, Huang, Gan, Zhu, Xu: "A novel IL-1RA-PEP fusion protein with enhanced brain penetration ameliorates cerebral ischemia-reperfusion injury by inhibition of oxidative stress and neuroinflammation." in: Experimental neurology, Vol. 297, pp. 1-13, 2017 (PubMed).

Feng, Cui, Gao, Li, Li, Jiang, Tian, Wang, Cui, Cui: "Resveratrol attenuates neuronal autophagy and inflammatory injury by inhibiting the TLR4/NF-κB signaling pathway in experimental traumatic brain injury." in: International journal of molecular medicine, Vol. 37, Issue 4, pp. 921-30, 2016 (PubMed).