COX2 Antikörper (Cytochrome C Oxidase Subunit II)

Details for Product anti-COX2 Antibody No. ABIN6269418
Target
Reaktivität
Human, Maus, Ratte
63
17
13
Wirt
Kaninchen
48
10
9
Klonalität
Polyklonal
Konjugat
Dieser COX2 Antikörper ist unkonjugiert
4
3
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
49
24
22
10
9
6
4
3
3
2
1
Optionen
Immunogen A synthesized peptide derived from human Cox2
Isotyp IgG
Spezifität Cox2 Antibody detects endogenous levels of total Cox2
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung Cox2 (COX2 Antibody Abstract)
Hintergrund

Description: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Gene: PTGS2

Molekulargewicht 80kDa
Gen-ID 5743
UniProt P35354
Pathways Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Applikations-hinweise WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Cytochrome C Oxidase Subunit II (COX2) antibody (ABIN6269418) Western blot analysis of Cox2 expression in A549 whole cell lysates,The lane on the l...
Image no. 2 for anti-Cytochrome C Oxidase Subunit II (COX2) antibody (ABIN6269418) ABIN6269419 staining A549 cells by ICC/IF. Cells were fixed with PFA and permeabilize...
Image no. 3 for anti-Cytochrome C Oxidase Subunit II (COX2) antibody (ABIN6269418) ABIN6269419 at 1/100 staining Human cervical cancer tissue by IHC-P. The sample was f...
Image no. 4 for anti-Cytochrome C Oxidase Subunit II (COX2) antibody (ABIN6269418) ABIN6269419 staining A549 by IF/ICC. The sample were fixed with PFA and permeabilized...
Produkt verwendet in: Yang, Wei, Song, Cai, Zhou, Peng, Jiang, Peng: "E4BP4 mediates glucocorticoid-regulated adipogenesis through COX2." in: Molecular and cellular endocrinology, Vol. 450, pp. 43-53, 2018 (PubMed).

Zhou, Qin, Li, Li, Wang, Zhang, Chen, Li: "Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 115, 2018 (PubMed).