EPH Receptor A4 Antikörper (EPHA4)

Details for Product anti-EPHA4 Antibody No. ABIN6268372
Target
Reaktivität
Human, Maus, Ratte
118
45
25
6
6
5
5
4
4
3
3
3
2
2
2
2
1
1
Wirt
Kaninchen
120
9
1
1
Klonalität
Polyklonal
Konjugat
Dieser EPH Receptor A4 Antikörper ist unkonjugiert
11
9
8
6
6
6
3
3
3
3
3
3
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
93
72
62
19
18
16
13
7
3
2
2
1
Optionen
Immunogen A synthesized peptide derived from human EPHA4
Isotyp IgG
Spezifität EPHA4 Antibody detects endogenous levels of EPHA4
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung EPHA4 (EPHA4 Antibody Abstract)
Hintergrund

Description: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Gene: EPHA4

Molekulargewicht 135kDa
Gen-ID 2043
UniProt P54764
Pathways RTK Signalweg
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-EPH Receptor A4 (EPHA4) antibody (ABIN6268372) Western blot analysis of EPHA4 in lysates of SNB19, using EPHA4 Antibody(ABIN6268373).