LRP5 Antikörper (Low Density Lipoprotein Receptor-Related Protein 5)

Details for Product anti-LRP5 Antibody No. ABIN6268314
Target
Reaktivität
Human, Maus, Ratte
82
76
43
1
1
Wirt
Kaninchen
88
7
6
1
Klonalität
Polyklonal
Konjugat
Dieser LRP5 Antikörper ist unkonjugiert
8
7
7
5
5
5
4
4
4
3
3
3
2
2
2
2
2
Applikation
ELISA, Western Blotting (WB)
64
45
31
29
8
3
3
3
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human LRP5
Isotyp IgG
Spezifität LRP5 Antibody detects endogenous levels of LRP5
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung LRP5 (LRP5 Antibody Abstract)
Hintergrund

Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (By similarity). Required for posterior patterning of the epiblast during gastrulation (By similarity).

Gene: LRP5

Molekulargewicht 200kDa
Gen-ID 4041
UniProt O75197
Pathways WNT Signalweg, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) antibody (ABIN6268314) Western blot analysis of LRP5 in lysates of SW620, using LRP5 Antibody(ABIN6268315).