Kinase Suppressor of Ras 2 (KSR2) Antikörper

Details zu Produkt Nr. ABIN6268308
Target
Reaktivität
Human, Maus, Ratte
62
18
2
Wirt
Kaninchen
54
8
Klonalität
Polyklonal
Konjugat
Unkonjugiert
6
5
5
4
4
4
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
53
44
20
17
11
6
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human KSR2
Isotyp IgG
Spezifität KSR2 Antibody detects endogenous levels of KSR2
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Target
Andere Bezeichnung KSR2 (KSR2 Antibody Abstract)
Hintergrund

Description: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Gene: KSR2

Molekulargewicht 115kDa
Gen-ID 283455
UniProt Q6VAB6
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Kinase Suppressor of Ras 2 (KSR2) antibody (ABIN6268308) Western blot analysis of KSR2 in lysates of HEK293, using KSR2 Antibody(ABIN6268309).