RIPK3 Antikörper (Receptor-Interacting serine-threonine Kinase 3) (pSer316)

Details for Product anti-RIPK3 Antibody No. ABIN6268222
Target
Bindungsspezifität
pSer316
16
11
9
9
9
7
5
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human
88
44
12
9
7
6
4
2
1
Wirt
Kaninchen
98
8
Klonalität
Polyklonal
Konjugat
Dieser RIPK3 Antikörper ist unkonjugiert
8
8
6
5
5
5
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
93
65
57
23
7
5
4
3
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human RIPK3 around the phosphorylation site of Ser316
Isotyp IgG
Spezifität Phospho-RIPK3(Ser316) Antibody detects endogenous levels of RIPK3 only when phosphorylated at Ser316
Kreuzreaktivität Human
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung RIPK3 (RIPK3 Antibody Abstract)
Hintergrund

Description: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Gene: RIPK3

Molekulargewicht 46-62kDa
Gen-ID 11035
UniProt Q9Y572
Pathways Activation of Innate immune Response, Toll-Like Receptors Cascades
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (pSer316) antibody (ABIN6268222) Western blot analysis of Phospho-RIPK3(Ser316) in lysates of HT29, using Phospho-RIPK...