ATF6 Antikörper (Activating Transcription Factor 6) (pThr166)

Details for Product anti-ATF6 Antibody No. ABIN6268220
Target
Bindungsspezifität
pThr166
15
12
11
8
8
7
4
4
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
104
44
35
4
4
4
3
3
3
2
1
Wirt
Kaninchen
78
19
8
Klonalität
Polyklonal
Konjugat
Dieser ATF6 Antikörper ist unkonjugiert
5
5
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
80
37
19
18
14
14
11
9
6
4
4
2
2
2
1
Optionen
Immunogen A synthesized peptide derived from human ATF6 around the phosphorylation site of Thr166
Isotyp IgG
Spezifität Phospho-ATF6 (Thr166) Antibody detects endogenous levels of ATF6 only when phosphorylated at Thr166
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung ATF6 (ATF6 Antibody Abstract)
Hintergrund

Description: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Gene: ATF6

Molekulargewicht 90-100kDa
Gen-ID 22926
UniProt P18850
Pathways ER-Nucleus Signaling, Unfolded protein response
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Activating Transcription Factor 6 (ATF6) (pThr166) antibody (ABIN6268220) Western blot analysis of Phospho-ATF6 (Thr166) in lysates of HeLa?, using Phospho-ATF...