PERK Antikörper (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3) (pSer1096)

Details for Product anti-EIF2AK3 Antibody No. ABIN6268204
Target
Bindungsspezifität
pSer1096
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Reaktivität
Human, Maus, Ratte
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81
77
Wirt
Kaninchen
137
5
3
1
Klonalität
Polyklonal
Konjugat
Dieser PERK Antikörper ist unkonjugiert
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Applikation
ELISA, Western Blotting (WB)
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Optionen
Immunogen A synthesized peptide derived from human perk around the phosphorylation site of S1096
Isotyp IgG
Spezifität Phospho-perk (S1096) Antibody detects endogenous levels of perk only when phosphorylated at S1096
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung perk (EIF2AK3 Antibody Abstract)
Hintergrund

Description: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

Gene: EIF2AK3

Molekulargewicht 125kDa
Gen-ID 9451
UniProt Q9NZJ5
Pathways Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) (pSer1096) antibody (ABIN6268204) Western blot analysis of Phospho-perk (S1096) in lysates of HepG2?, using Phospho-per...