RAN Binding Protein 3 (RANBP3) (pSer126) Antikörper

Details zu Produkt Nr. ABIN6268196
Target
Bindungsspezifität
pSer126
15
11
8
7
2
2
2
2
1
1
1
Reaktivität
Human
48
18
16
1
1
1
1
Wirt
Kaninchen
43
5
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
32
22
13
3
3
2
2
2
Optionen
Immunogen A synthesized peptide derived from human RanBP3 around the phosphorylation site of Ser126
Isotyp IgG
Spezifität Phospho-RanBP3 (Ser126) Antibody detects endogenous levels of RanBP3 only when phosphorylated at Ser126
Kreuzreaktivität Human
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung RanBP3 (RANBP3 Antibody Abstract)
Hintergrund

Description: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

Gene: RANBP3

Molekulargewicht 70kDa
Gen-ID 8498
UniProt Q9H6Z4
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-RAN Binding Protein 3 (RANBP3) (pSer126) antibody (ABIN6268196) Western blot analysis of Phospho-RanBP3 (Ser126) in lysates of HeLa?, using Phospho-R...