PINK1 Antikörper (PTEN Induced Putative Kinase 1) (pThr313)

Details for Product anti-PINK1 Antibody No. ABIN6268188
Target
Bindungsspezifität
pThr313
41
17
12
9
8
7
7
7
7
7
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
138
89
61
2
2
1
1
1
Wirt
Kaninchen
96
58
7
1
Klonalität
Polyklonal
Konjugat
Dieser PINK1 Antikörper ist unkonjugiert
11
10
8
8
8
8
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
135
86
80
34
28
9
4
3
2
1
1
Optionen
Immunogen A synthesized peptide derived from human PINK1 around the phosphorylation site of T313
Isotyp IgG
Spezifität Phospho-PINK1 ( T313) Antibody detects endogenous levels of PINK1 only when phosphorylated at T313
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung PINK1 (PINK1 Antibody Abstract)
Hintergrund

Description: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).

Gene: PINK1

Molekulargewicht 66kDa
Gen-ID 65018
UniProt Q9BXM7
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-PTEN Induced Putative Kinase 1 (PINK1) (pThr313) antibody (ABIN6268188) Western blot analysis of Phospho-PINK1 ( T313) in lysates of Jurkat?, using Phospho-P...