CAMKK2 Antikörper (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta) (pSer511)

Details for Product anti-CAMKK2 Antibody No. ABIN6268180
Target
Bindungsspezifität
pSer511
20
9
9
7
7
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
77
50
29
3
2
2
2
1
1
1
1
1
1
Wirt
Kaninchen
83
9
Klonalität
Polyklonal
Konjugat
Dieser CAMKK2 Antikörper ist unkonjugiert
7
6
6
4
4
4
2
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
75
49
29
14
13
6
5
4
2
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human CaMKK2 around the phosphorylation site of Ser511
Isotyp IgG
Spezifität Phospho-CaMKK2 (Ser511) Antibody detects endogenous levels of CaMKK2 only when phosphorylated at Ser511
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung CaMKK2 (CAMKK2 Antibody Abstract)
Hintergrund

Description: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Gene: CAMKK2

Molekulargewicht 68kDa
Gen-ID 10645
UniProt Q96RR4
Pathways AMPK Signaling
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2) (pSer511) antibody (ABIN6268180) Western blot analysis of Phospho-CaMKK2 (Ser511) in lysates of Rat brain, using Phosp...