Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) (pSer342) Antikörper

Details zu Produkt Nr. ABIN6268178
Target
Bindungsspezifität
pSer342
15
9
8
8
7
7
4
3
2
2
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
61
57
32
5
4
4
4
3
3
1
1
1
1
1
Wirt
Kaninchen
71
5
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
4
4
4
4
4
4
4
4
2
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
46
28
13
9
5
5
3
2
1
1
Optionen
Immunogen A synthesized peptide derived from human NEDD4L around the phosphorylation site of Ser342
Isotyp IgG
Spezifität Phospho-NEDD4L (Ser342) Antibody detects endogenous levels of NEDD4L only when phosphorylated at Ser342
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung NEDD4L (NEDD4L Antibody Abstract)
Hintergrund

Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338).

Gene: NEDD4L

Molekulargewicht 112kDa
Gen-ID 23327
UniProt Q96PU5
Pathways Negative Regulation of Transporter Activity
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) (pSer342) antibody (ABIN6268178) Western blot analysis of Phospho-NEDD4L (Ser342) in lysates of K562?, using Phospho-...