F2RL3 Antikörper (Coagulation Factor II (Thrombin) Receptor-Like 3) (pThr163)

Details for Product anti-F2RL3 Antibody No. ABIN6268176
Target
Bindungsspezifität
pThr163
15
5
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
66
35
35
2
1
1
1
1
1
1
Wirt
Kaninchen
58
9
1
Klonalität
Polyklonal
Konjugat
Dieser F2RL3 Antikörper ist unkonjugiert
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
43
27
13
13
12
7
5
3
2
2
2
1
Optionen
Immunogen A synthesized peptide derived from human PAR-4 around the phosphorylation site of Thr163
Isotyp IgG
Spezifität Phospho-PAR-4 (Thr163) Antibody detects endogenous levels of PAR-4 only when phosphorylated at Thr163
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung PAR-4 (F2RL3 Antibody Abstract)
Hintergrund

Description: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Gene: PAWR

Molekulargewicht 43kDa
Gen-ID 5074
UniProt Q96IZ0
Pathways Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3) (pThr163) antibody (ABIN6268176) Western blot analysis of Phospho-PAR-4 (Thr163) in lysates of HeLa?, using Phospho-PA...