Sphingomyelin Synthase 1 Antikörper (SGMS1) (pThr12)

Details for Product anti-SGMS1 Antibody No. ABIN6268166
Target
Bindungsspezifität
pThr12
15
8
8
7
4
2
1
1
1
Reaktivität
Human, Maus, Ratte
42
22
21
3
3
3
3
3
2
2
2
1
Wirt
Kaninchen
42
Klonalität
Polyklonal
Konjugat
Dieser Sphingomyelin Synthase 1 Antikörper ist unkonjugiert
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
27
21
17
13
4
1
1
Optionen
Immunogen A synthesized peptide derived from human MOB1 around the phosphorylation site of Thr12
Isotyp IgG
Spezifität Phospho-MOB1 (Thr12) Antibody detects endogenous levels of MOB1 only when phosphorylated at Thr12
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung MOB1 (SGMS1 Antibody Abstract)
Hintergrund

Description: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Gene: MOB1B

Molekulargewicht 25kDa
Gen-ID 92597
UniProt Q7L9L4
Pathways Cellular Response to Molecule of Bacterial Origin
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Sphingomyelin Synthase 1 (SGMS1) (pThr12) antibody (ABIN6268166) Western blot analysis of Phospho-MOB1 (Thr12) in lysates of 293 IFN 2500U/ml 30', us...