IRF4 Antikörper (Interferon Regulatory Factor 4) (pTyr122)

Details for Product anti-IRF4 Antibody No. ABIN6268158
Target
Bindungsspezifität
pTyr122, pTyr125
16
7
7
5
5
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
81
37
27
4
4
4
3
3
3
3
2
2
2
2
1
Wirt
Kaninchen
58
15
9
2
1
Klonalität
Polyklonal
Konjugat
Dieser IRF4 Antikörper ist unkonjugiert
4
3
2
2
2
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
71
38
28
17
14
10
8
3
3
3
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human phospho-IRF4 around the phosphorylation site of Y122/125
Isotyp IgG
Spezifität Phospho-IRF4(Y122/125) antibod detects endogenous levels of phospho-IRF4 only when phosphorylated at Y122/125
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung IRF4 (IRF4 Antibody Abstract)
Hintergrund

Description: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).

Gene: IRF4

Molekulargewicht 51kDa
Gen-ID 3662
UniProt Q15306
Pathways Chromatin Binding
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Interferon Regulatory Factor 4 (IRF4) (pTyr122), (pTyr125) antibody (ABIN6268158) Western blot analysis of phospho-IRF4(Y122/125) antibod in lysates of Karpas-620, usi...