SMC1A Antikörper (Structural Maintenance of Chromosomes 1A) (pSer360)

Details for Product anti-SMC1A Antibody No. ABIN6268152
Target
Bindungsspezifität
pSer360
25
16
15
12
10
9
7
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
153
77
55
7
7
6
5
4
4
3
3
2
2
1
1
1
Wirt
Kaninchen
125
24
3
2
1
Klonalität
Polyklonal
Konjugat
Dieser SMC1A Antikörper ist unkonjugiert
9
7
7
7
6
6
6
4
4
3
2
2
2
2
2
2
2
Applikation
ELISA, Western Blotting (WB)
103
47
40
27
25
24
15
7
6
4
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human SMC1 around the phosphorylation site of Ser360
Isotyp IgG
Spezifität Phospho-SMC1 (Ser360) Antibody detects endogenous levels of SMC1 only when phosphorylated at Ser360
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung SMC1 (SMC1A Antibody Abstract)
Hintergrund

Description: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

Gene: SMC1A

Molekulargewicht 145kDa
Gen-ID 8243
UniProt Q14683
Pathways Stem Cell Maintenance
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Structural Maintenance of Chromosomes 1A (SMC1A) (pSer360) antibody (ABIN6268152) Western blot analysis of Phospho-SMC1 (Ser360) in lysates of 293 UV, using Phospho-S...