SCRIB Antikörper (Scribbled Homolog (Drosophila)) (pSer1220)

Details for Product anti-SCRIB Antibody No. ABIN6268148
Target
Bindungsspezifität
pSer1220
8
8
7
3
1
1
Reaktivität
Human, Maus
30
9
9
1
Wirt
Kaninchen
30
Klonalität
Polyklonal
Konjugat
Dieser SCRIB Antikörper ist unkonjugiert
3
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
23
19
5
2
1
1
Optionen
Immunogen A synthesized peptide derived from human Scribble around the phosphorylation site of Ser1220
Isotyp IgG
Spezifität Phospho-Scribble (Ser1220) Antibody detects endogenous levels of Scribble only when phosphorylated at Ser1220
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung Scribble (SCRIB Antibody Abstract)
Hintergrund

Description: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.

Gene: SCRIB

Molekulargewicht 240kDa
Gen-ID 23513
UniProt Q14160
Pathways Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Tube Formation, Synaptic Vesicle Exocytosis, Asymmetric Protein Localization
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Scribbled Homolog (Drosophila) (SCRIB) (pSer1220) antibody (ABIN6268148) Western blot analysis of Phospho-Scribble (Ser1220) in lysates of HCT 116, using Phos...