RUNX2 Antikörper (Runt-Related Transcription Factor 2) (pSer340)

Details for Product anti-RUNX2 Antibody No. ABIN6268146
Target
Bindungsspezifität
pSer340
22
10
10
9
8
8
8
7
7
7
5
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
171
84
70
12
11
9
9
8
8
6
5
5
4
3
3
2
2
1
1
1
Wirt
Kaninchen
152
22
2
Klonalität
Polyklonal
Konjugat
Dieser RUNX2 Antikörper ist unkonjugiert
11
7
7
7
7
7
7
7
6
3
3
3
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
110
70
50
21
14
13
11
9
8
5
2
2
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human RUNX2 around the phosphorylation site of S340
Isotyp IgG
Spezifität RUNX2 (Phospho-S340) Antibody detects endogenous levels of RUNX2 only when phosphorylated at S340
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung RUNX2 (RUNX2 Antibody Abstract)
Hintergrund

Description: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

Gene: RUNX2

Molekulargewicht 50-60kDakDa
Gen-ID 860
UniProt Q13950
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Runt-Related Transcription Factor 2 (RUNX2) (pSer340) antibody (ABIN6268146) Western blot analysis of RUNX2 (Phospho-S340) in lysates of Mouse thymus?, using RUNX...