ATR (pThr1989) Antikörper

Details zu Produkt Nr. ABIN6268140
Target
Bindungsspezifität
pThr1989
12
10
5
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
68
13
8
7
4
3
1
1
1
1
Wirt
Kaninchen
59
8
8
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
4
3
2
2
2
2
2
2
2
2
2
Applikation
ELISA, Western Blotting (WB)
46
40
27
7
4
2
2
2
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human ATR around the phosphorylation site of Thr1989
Isotyp IgG
Spezifität Phospho-ATR (Thr1989) Antibody detects endogenous levels of ATR only when phosphorylated at Thr1989
Kreuzreaktivität Human
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Hintergrund

Description: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Gene: ATR

Molekulargewicht 300kDa
Gen-ID 545
UniProt Q13535
Pathways Positive Regulation of Response to DNA Damage Stimulus
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-ATR (pThr1989) antibody (ABIN6268140) Western blot analysis of Phospho-ATR (Thr1989) in lysates of HeLa?, using Phospho-ATR...