GRIN2B Antikörper (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (pTyr1070)

Details for Product anti-GRIN2B Antibody No. ABIN6268134
Target
Bindungsspezifität
pTyr1070
85
47
26
23
19
18
18
15
15
15
15
15
15
12
8
7
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
306
304
280
19
15
10
9
6
5
4
4
3
2
2
2
2
2
2
1
1
Wirt
Kaninchen
231
100
7
Klonalität
Polyklonal
Konjugat
Dieser GRIN2B Antikörper ist unkonjugiert
17
12
12
12
10
10
10
10
10
7
7
7
7
7
5
5
5
4
4
4
4
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
Applikation
ELISA, Western Blotting (WB)
224
135
104
91
67
58
48
46
37
26
11
8
4
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human NMDAR2B around the phosphorylation site of Tyr1070
Isotyp IgG
Spezifität Phospho-NMDAR2B (Tyr1070) Antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyr1070
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung NMDAR2B (GRIN2B Antibody Abstract)
Hintergrund

Description: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).

Gene: GRIN2B

Molekulargewicht 165kDa
Gen-ID 2904
UniProt Q13224
Pathways Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B) (pTyr1070) antibody (ABIN6268134) Western blot analysis of Phospho-NMDAR2B (Tyr1070) in lysates of Jurkat , using Phosp...