CDC20 Antikörper (Cell Division Cycle 20 Homolog (S. Cerevisiae)) (pSer51)

Details for Product anti-CDC20 Antibody No. ABIN6268124
Target
Bindungsspezifität
pSer51
13
10
8
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
83
32
28
7
4
3
3
3
3
2
1
1
1
1
Wirt
Kaninchen
62
24
Klonalität
Polyklonal
Konjugat
Dieser CDC20 Antikörper ist unkonjugiert
6
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
56
40
28
23
22
14
7
5
2
2
2
Optionen
Immunogen A synthesized peptide derived from human CDC20 around the phosphorylation site of Ser51
Isotyp IgG
Spezifität Phospho-CDC20 (Ser51) Antibody detects endogenous levels of CDC20 only when phosphorylated at Ser51
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung CDC20 (CDC20 Antibody Abstract)
Hintergrund

Description: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Gene: CDC20

Molekulargewicht 50kDa
Gen-ID 991
UniProt Q12834
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) (pSer51) antibody (ABIN6268124) Western blot analysis of Phospho-CDC20 (Ser51) in lysates of Jurkat , using Phospho-C...