FOXL2 Antikörper (Forkhead Box L2) (pSer238)

Details for Product anti-FOXL2 Antibody No. ABIN6268106
Target
Bindungsspezifität
pSer238
17
15
9
9
8
4
1
1
1
1
1
1
Reaktivität
Human, Maus
73
33
23
7
7
6
5
5
2
2
1
Wirt
Kaninchen
64
7
2
Klonalität
Polyklonal
Konjugat
Dieser FOXL2 Antikörper ist unkonjugiert
6
5
5
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
47
31
18
13
4
4
1
1
1
Optionen
Immunogen A synthesized peptide derived from human FOXL2 around the phosphorylation site of Ser238
Isotyp IgG
Spezifität FOXL2 (Phospho-Ser238) Antibody detects endogenous levels of FOXL2 only when phosphorylated at Ser238
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung FOXL2 (FOXL2 Antibody Abstract)
Hintergrund

Description: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

Gene: FOXL2

Molekulargewicht 50kDa
Gen-ID 668
UniProt P58012
Pathways Nuclear Hormone Receptor Binding, Positive Regulation of Endopeptidase Activity
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Forkhead Box L2 (FOXL2) (pSer238) antibody (ABIN6268106) Western blot analysis of FOXL2 (Phospho-Ser238) in lysates of Jurkat?, using FOXL2 (P...