TSC2 Antikörper (Tuberous Sclerosis 2) (pSer1387)

Details for Product anti-TSC2 Antibody No. ABIN6268080
Target
Bindungsspezifität
pSer1387
33
28
24
19
19
18
17
16
15
15
15
15
15
14
14
13
13
9
9
9
9
9
9
9
9
9
9
9
9
9
8
8
8
8
8
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
421
333
216
9
9
2
2
1
1
1
1
1
Wirt
Kaninchen
495
24
Klonalität
Polyklonal
Konjugat
Dieser TSC2 Antikörper ist unkonjugiert
42
42
35
26
25
25
16
14
14
14
14
14
9
9
9
9
9
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
246
196
150
120
102
48
39
9
8
7
7
5
3
1
Optionen
Immunogen A synthesized peptide derived from human Tuberin/TSC2 around the phosphorylation site of Ser1387
Isotyp IgG
Spezifität Phospho-Tuberin/TSC2 (Ser1387) Antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Ser1387
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung Tuberin/TSC2 (TSC2 Antibody Abstract)
Hintergrund

Description: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).

Gene: TSC2

Molekulargewicht 200kDa
Gen-ID 7249
UniProt P49815
Pathways RTK Signalweg, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Tuberous Sclerosis 2 (TSC2) (pSer1387) antibody (ABIN6268080) Western blot analysis of Phospho-Tuberin/TSC2 (Ser1387) in lysates of 293 Anisomycin ...