SREBF1 Antikörper (Sterol Regulatory Element Binding Transcription Factor 1) (pSer396)

Details for Product anti-SREBF1 Antibody No. ABIN6268064
Target
Bindungsspezifität
pSer396
13
10
10
8
7
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
87
35
30
8
6
5
4
4
2
2
1
1
1
1
Wirt
Kaninchen
80
12
Klonalität
Polyklonal
Konjugat
Dieser SREBF1 Antikörper ist unkonjugiert
5
4
3
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
ELISA, Western Blotting (WB)
74
46
24
7
6
5
4
4
2
2
1
1
Optionen
Immunogen A synthesized peptide derived from human SREBP-1c around the phosphorylation site of Ser396
Isotyp IgG
Spezifität Phospho-SREBP-1c (Ser396) Antibody detects endogenous levels of SREBP-1c only when phosphorylated at Ser396
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung SREBP-1c (SREBF1 Antibody Abstract)
Hintergrund

Description: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').

Gene: SREBF1

Molekulargewicht 122kDa
Gen-ID 6720
UniProt P36956
Pathways AMPK Signaling, Caspase Kaskade in der Apoptose, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) (pSer396) antibody (ABIN6268064) Western blot analysis of Phospho-SREBP-1c (Ser396) in lysates of Jurkat TNF 20ng/ml 3...