FLT3 Antikörper (Fms-Related tyrosine Kinase 3) (pTyr842)

Details for Product anti-FLT3 Antibody No. ABIN6268062
Target
Bindungsspezifität
pTyr842
20
19
18
17
16
11
10
9
8
8
7
7
5
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
191
109
35
6
1
1
1
1
1
1
Wirt
Kaninchen
190
21
2
1
Klonalität
Polyklonal
Konjugat
Dieser FLT3 Antikörper ist unkonjugiert
16
12
10
8
8
7
7
7
7
7
7
6
4
4
4
4
4
Applikation
ELISA, Western Blotting (WB)
113
85
53
31
28
27
12
9
9
4
2
1
1
1
1
1
Optionen
Immunogen A synthesized peptide derived from human FLT3 around the phosphorylation site of Tyr842
Isotyp IgG
Spezifität Phospho-FLT3 (Tyr842) Antibody detects endogenous levels of FLT3 only when phosphorylated at Tyr842
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung FLT3 (FLT3 Antibody Abstract)
Hintergrund

Description: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Gene: FLT3

Molekulargewicht 113kDa
Gen-ID 2322
UniProt P36888
Pathways RTK Signalweg
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Fms-Related tyrosine Kinase 3 (FLT3) (pTyr842) antibody (ABIN6268062) Western blot analysis of Phospho-FLT3 (Tyr842) in lysates of COS7 EGF 200ng/ml 30', u...