Insulin Receptor Substrate 1 (IRS1) (pSer318) Antikörper

Details zu Produkt Nr. ABIN6268052
Target
Bindungsspezifität
pSer318
34
28
26
23
20
20
18
16
16
15
15
15
15
15
13
13
11
11
9
5
5
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
379
295
279
23
12
4
3
2
2
1
1
Wirt
Kaninchen
384
14
Klonalität
Polyklonal
Konjugat
Unkonjugiert
22
19
14
14
14
14
14
12
11
10
10
10
10
10
2
2
1
1
1
Applikation
ELISA, Western Blotting (WB)
212
138
130
102
81
67
24
21
16
12
10
4
3
1
1
Optionen
Immunogen A synthesized peptide derived from human IRS-1 around the phosphorylation site of Ser318
Isotyp IgG
Spezifität Phospho-IRS-1 (Ser318) Antibody detects endogenous levels of IRS-1 only when phosphorylated at Ser318
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung IRS-1 (IRS1 Antibody Abstract)
Hintergrund

Description: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Gene: IRS1

Molekulargewicht 180kDa
Gen-ID 3667
UniProt P35568
Pathways Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Insulin Receptor Substrate 1 (IRS1) (pSer318) antibody (ABIN6268052) Western blot analysis of Phospho-IRS-1 (Ser318) in lysates of 293T insulin, using Ph...