Opioid Receptor, kappa 1 (OPRK1) (pSer369) Antikörper

Details zu Produkt Nr. ABIN6268046
Target
Bindungsspezifität
pSer369
15
15
12
10
10
7
3
3
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
55
46
36
2
1
1
1
1
1
1
1
Wirt
Kaninchen
73
7
5
Klonalität
Polyklonal
Konjugat
Unkonjugiert
6
4
4
4
4
4
2
2
2
2
2
2
1
Applikation
ELISA, Western Blotting (WB)
62
50
20
9
4
3
3
2
1
1
1
Optionen
Immunogen A synthesized peptide derived from human KOR-1 around the phosphorylation site of Ser369
Isotyp IgG
Spezifität KOR-1 (Phospho-Ser369) Antibody detects endogenous levels of KOR-1 only when phosphorylated at Ser369
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung KOR-1 (OPRK1 Antibody Abstract)
Hintergrund

Description: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Gene: OPRK1

Molekulargewicht 58kDa
Gen-ID 4986
UniProt P41145
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Opioid Receptor, kappa 1 (OPRK1) (pSer369) antibody (ABIN6268046) Western blot analysis of KOR-1 (Phospho-Ser369) in lysates of Mouse brain, using KOR-...