TRKA Antikörper (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (pTyr785)

Details for Product anti-NTRK1 Antibody No. ABIN6267988
Target
Bindungsspezifität
pTyr785
37
24
15
15
15
13
12
12
12
12
11
10
10
10
10
10
9
9
6
5
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte
303
212
165
2
1
Wirt
Kaninchen
291
31
3
3
1
Klonalität
Polyklonal
Konjugat
Dieser TRKA Antikörper ist unkonjugiert
24
17
16
14
11
11
11
9
9
9
8
8
7
7
7
7
7
2
2
1
1
Applikation
ELISA, Western Blotting (WB)
186
121
88
75
39
39
23
23
10
8
5
4
4
1
1
Optionen
Immunogen A synthesized peptide derived from human TrkA around the phosphorylation site of Tyr785
Isotyp IgG
Spezifität Phospho-TrkA (Tyr785) /TrkB (Tyr816) Antibody detects endogenous levels of TrkA only when phosphorylated at Tyr785
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung TrkA (NTRK1 Antibody Abstract)
Hintergrund

Description: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

Gene: NTRK1

Molekulargewicht 87kDa
Gen-ID 4914
UniProt P04629
Pathways RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr785) antibody (ABIN6267988) Western blot analysis of Phospho-TrkA (Tyr785) /TrkB (Tyr816) in lysates of jurkat?, ...