ULK1 Antikörper (Unc-51 Like Kinase 1 (C. Elegans)) (pSer638)

Details for Product anti-ULK1 Antibody No. ABIN6267980
Target
Bindungsspezifität
pSer638
31
29
24
16
15
15
15
10
10
9
9
9
8
8
7
7
7
7
7
7
4
4
4
3
3
2
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus
244
126
106
6
4
4
2
2
2
2
2
2
1
1
1
1
1
Wirt
Kaninchen
242
4
2
Klonalität
Polyklonal
Konjugat
Dieser ULK1 Antikörper ist unkonjugiert
25
17
16
12
12
12
11
9
9
9
9
9
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
150
119
33
29
28
26
24
14
12
3
3
2
1
Optionen
Immunogen A synthesized peptide derived from human ULK1 around the phosphorylation site of Ser638
Isotyp IgG
Spezifität Phospho-ULK1 (Ser638) Antibody detects endogenous levels of ULK1 only when phosphorylated at Ser638
Kreuzreaktivität Human, Maus
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Target
Andere Bezeichnung ULK1 (ULK1 Antibody Abstract)
Hintergrund

Description: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

Gene: ULK1

Molekulargewicht 120kDa
Gen-ID 8408
UniProt O75385
Pathways Regulation of Cell Size, Autophagie
Applikations-hinweise WB 1:500-1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months
Bilder
Image no. 1 for anti-Unc-51 Like Kinase 1 (C. Elegans) (ULK1) (pSer638) antibody (ABIN6267980) Western blot analysis of Phospho-ULK1 (Ser638) in lysates of PC12?, using Phospho-ULK...